Cytokines and Chemokines in Autoimmune Disease (Advances in Experimental Medicine and Biology)



Publisher: Springer

Written in English
Cover of: Cytokines and Chemokines in Autoimmune Disease (Advances in Experimental Medicine and Biology) |
Published: Pages: 316 Downloads: 341
Share This

Subjects:

  • Biology, Life Sciences,
  • Cytology,
  • Mechanisms Of Immune Response,
  • Medical,
  • Medical / Nursing,
  • Diseases,
  • Immunology,
  • Medical / Immunology,
  • Medical-Diseases,
  • Science / Biology,
  • Life Sciences - Cytology

Edition Notes

Shachar I, Karin N. The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications. J Leukoc Biol. ;93(1)– doi: /jlb Sinha R, Sinha L, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie Jr JP. Each of these different cytokines perform different functions including regulating immunity (and autoimmune disease), inflammation, homeostasis (stability), and blood cell production. 3 Tumor necrosis factor (TNF) and interleukin-6 (IL-6) are examples of pro-inflammatory cytokines.   In immune-mediated inflammation, TH1 and TH17 cells secrete cytokines that recruit and activate leukocytes. IL, produced by TH17 cells, promotes neutrophil recruitment; interferon-y (IFN-y), produced by TH1 cells, activates macrophages; and tumor necrosis factor (TNF) and chemokines, produced by T lymphocytes and other cells, are involved in the recruitment and activation of many . Abstract. Cytokines play an important role in the induction and regulation of autoimmune diseases. They mediate the expansion and differentiation of T helper (Th) cells to generate autoantigen-reactive pathogenic or protective effectors, they help self-reactive B cells to produce autoantibodies, and they also participate in mediating tissue damage in the target organ.

The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. According to the Autoimmune Diseases Coordinating Committee (ADCC), between and million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead. Cytokines & Chemokines can be grouped into functionally related Families. 2 “The Autoimmune Limb Graft-vs-Host disease Chemokines Chemokines signal through G-protein coupled receptors making them desirable drug targets Chemokine Redundancy Abbas Chpt. Cytokine disturbances have been implicated, but not always well understood, in other autoimmune disorders as well. According to Dr. Ivashkiv, there are hundreds of cytokines and their network of.

Several cytokines and chemokines involved in the induction or regulation of inflammatory responses were shown to associate with the severe and persistent symptoms in CHIKV infection. Further studies on the difference in immune responses observed in an autoimmune disease, rheumatoid arthritis, infectious disease, and CHIKV infection, would. Keywords:Chemokines, autoimmunity, autoimmune thyroid disease, CXCL9, CXCL10, CXCL11, CXCR3, Graves' disease, Hashimoto's thyroiditis, psoriasis. Abstract: The recruitment, trafficking, and in situ maintenance of specific subsets of activated lymphocytes constitute crucial steps for the initiation and perpetuation of chronic autoimmune. Title: Chemokines as Novel Therapeutic Targets in Autoimmune Thyroiditis VOLUME: 4 ISSUE: 1 Author(s):Yujiang Fang, Lei Zhao and Feng Yan Affiliation:Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA Keywords:Chemokine, thyroiditis, autoimmunity Abstract: Chemokines, a group of proinflammatory chemotactic cytokines, function to recruit leukocytes to.

Cytokines and Chemokines in Autoimmune Disease (Advances in Experimental Medicine and Biology) Download PDF EPUB FB2

The different Chapters of this book detail the role of different cytokines and chemokines in specific autoimmune disorders. In this Chapter, I highlight the contributions of individual cytokines and chemokines Cytokines and Chemokines in Autoimmune Disease book multiple autoimmune diseases as discussed in detail throughout the book.1–14 The reader is referred to specific Chapters for Cited by: Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases.

The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of 3/5(1). The role of cytokines and chemokines in each of these disorders is dissected in the context of the autoinimune responses that drive these diseases.

Importantly, each chapter is meant to provide an in-depth review of how cytokines and chemokines participate in each disease, rather than very specific aspects of cytokine or chemokine biology.

Cytokines and Chemokines in Autoimmune Disease by Pere Santamaria,available at Book Depository with free delivery :   Importantly, each chapter is meant to provide an in-depth review of how cytokines and chemokines participate in each disease, rather than very specific aspects of cytokine or chemokine biology.

The book therefore provides an integrated view of how multiple cytokines and chemokines participate in the initiation and evolution of both systemic and Author: Pere Santamaria.

Cytokines and Autoimmune Diseases Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases.

Medical books Cytokines and Autoimmune Diseases. Medical books Cytokines and Autoimmune Diseases. Authoritative and state-of-the-art, Cytokines and Autoimmune Diseases comprehensively integrates the diffuse literature of this dramatically advancing field, and highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

What role do cytokines play in autoimmune diseases. Date: Decem Source: Mary Ann Liebert, Inc., Publishers Summary: Cytokines, a varied group of signaling chemicals in the body, have.

These signals include cytokines and chemokines from other immune cells as well as environmental signals that bind pattern recognition receptors such as Toll-like receptors.

This chapter presents our current understanding of DC subsets, function, and relation to autoimmune disease. Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases.

human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights. Figure ive breakdown of B cell tolerance to key inflammatory cytokines/chemokines regulates cancer, autoimmunity and infectious diseases: selective breakdown of tolerance to chemokines and cytokines may result from the generation of an inflammatory process at sites that are partially restricted from immune surveillance (autoimmune sites, tumor sites) or as a results of a deficiency in.

An international group of researchers has found that the cytokine IL is heavily involved in autoimmune and inflammatory diseases, opening the door to new therapies targeting the molecule.

Research at the VIB-UGent Center for Inflammation Research has identified a crucial molecular mechanism underlying autoimmune and inflammatory diseases like psoriasis, rheumatoid arthritis.

As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin Get this from a library.

Cytokines and chemokines in autoimmune disease. [Pere Santamaria;] -- This book attempts to capture recent knowledge on the role of cytokines and chemokines in autoimmunity by focusing on some of the most prevalent organ-specific or systemic autoimmune disorders.

After. To understand the genesis of these lymphoid follicles, the expression of relevant cytokines and chemokines was assessed by real time PCR, immunohistochemistry and by in vitro assays in autoimmune.

Cytokines are released by immune cells for the signalling function, and also can be used to identify what type of cell they are.

While, chemokines are one type cytokines that has a more speicific. The precise pathomechanisms of human autoimmune diseases are still poorly understood.

However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have.

This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Show less The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all.

The uncontrolled production of the pro-inflammatory cytokines involved in autoimmunity suggests the need to find new therapeutic targets in order to alleviate the disease. Some anti-inflammatory cytokines have recently been described to suppress inflammation by nonspecific inhibition of several cytokines and chemokines.

The levels of several of the cytokines, cytokine receptors, and chemokines were significantly increased in individuals before disease onset compared with the levels in control subjects; i.e., those representing signs of general immune activation (interleukin‐1β [IL‐1β], IL‐2, IL‐6, IL‐1 receptor antagonist, and tumor necrosis factor.

Cytokines: role in specific autoimmune diseases --Cytokines and resistance to organ specific autoimmune disease / Benjamin M. Segal --The role of cytokines in induction and regulation of autoimmune uveitis / Rachel R.

Caspi --Pathogenic and regulatory cytokines in experimental autoimmune encephalomyelitis / Estelle Bettelli --Role of cytokines. Cytokines and chemokines could also be affected by the systemic inflammatory disorders, including myositis, dermatitis and interstitial lung disease (ILD) in DM.

10 Therefore, we investigated the association between cytokines and chemokines and clinical severity, especially cutaneous lesions and ILD. Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases.

human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights Brand: Humana Press. Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases.

The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation. Cytokines and Chemokines in Autoimmune Disease, edited by Pere Santamaria, Landes / Kluwer dual imprint/ Advances in Experimental Medicine and Biology VolumeISBN   (cytokines that amplify and perpetuate the inflammatory process), growth factors (cytokines that promote cell survival and result in structural changes in the airways), chemokines (cytokines that are chemotactic for inflammatory cells) and anti-inflammatory cytokines (cytokines that negatively modulate the inflammatory response) [3].

The disease is often disabling, leading to loss of organ function and decreased productivity, requiring extensive care. Since cures are not available for any of the autoimmune diseases and most are unremitting, patients may face a lifetime of debilitating illness and costly treatment.

Chemokines, small cytokines primarily responsible for leucocyte migration Cytokines function as part of a larger inter-related system of proteins and signaling cascades, the cytokine network.

These are complex interactions in which different cells can respond differently to the same cytokine depending upon other signals received by the cell.

Cytokines, including proinflammatory cytokines and anti-inflammatory cytokines, are important players in the pathogenesis of these diseases through multiple ways, such as regulating inflammation and angiogenesis.

In this special issue, we present original research articles as well as review papers on the role of cytokines in autoimmune diseases.

CYTOKINE-BASED IMMUNOINTERVENTION. Cytokines are essential components of the immune response, and an imbalance in the cytokine network plays an important role in the initiation and perpetuation of autoimmune diseases [].Although preclinical models do not always predict accurately the efficacy of cytokine manipulation in human patients, considerable progress is being made in cytokine.

The chapter describes several noteworthy examples of these virally encoded cytokines and receptors together with their roles in vivo. This is a well-written book that provides a good introduction to understanding how cytokines and chemokines interact as a network in the immune system.The multiple cytokines detected in the extracellular milieu at any given time during an immunological response can interact in pleiotropic (different effects on different types of target cells), redundant (multiple cytokines have same effect), synergic (cooperative effect of multiple cytokines), antagonistic (inhibition of one cytokines effects by another) and cascade induction (multiple-step.Since publication of the 4th Edition of The Autoimmune Diseases inthe understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.

This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune .